MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT
About This Grant
PROJECT SUMMARY/ABSTRACT The axon initial segment (AIS) governs key processes of action potential generation and neuronal polarity. The functions of AIS are often perturbed in brain conditions such as autism spectrum disorder (ASD). Given its prominent placement and crucial role in dynamic neuronal signaling and communication, the AIS has long been recognized as a hotspot for protein phosphorylation. However, our knowledge of the AIS-specific phospho- regulators, i.e., kinases and phosphatases, is surprisingly lacking. Without this critical information, researchers face a significant challenge in understanding how protein phosphorylation at the AIS is regulated in health and impacted in various brain conditions. In this proposal, we will identify unique protein phosphatase subunits enriched at the AIS, and uncover the distinct molecular mechanisms that recruit them to the AIS (Aim 1). We will then dissect the molecular, electrophysiological, and behavioral phenotypes associated with these subunits by experimentally perturbing their expression (Aim 2). Finally, we will investigate how AIS-enriched kinases contribute to the regulation of AIS cytoskeletal dynamics and the neuronal activity adaptation during plasticity (Aim 3). In summary, we aim to identify new mechanisms underlying the AIS enrichment of specific factors that regulate protein phosphorylation, and elucidate their distinct contributions to AIS function, neuronal signaling, and behavior. The successful completion of this project will significantly advance the field of AIS neurobiology, and provide critical insights into the pathophysiology of brain disorders related to AIS functions.
Grant Summary
MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT is a NIMH - National Institute of Mental Health grant providing up to $701K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $701K
2031-03-31
- 1Confirm your organization is eligible for MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT: Frequently Asked Questions
Who is eligible for the MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT?
MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT provide?
MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT provides up to $701K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT deadline?
Applications for MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT?
To apply for MECHANISMS OF PROTEIN PHOSPHORYLATION AT THE AXON INITIAL SEGMENT, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.