Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk
About This Grant
Psychotic disorders are a leading contributor to the global disease burden, causing high levels of disability and increased mortality. To improve outcomes, it is essential to identify and treat patients in the early stages of psychotic disorders, especially before overt symptoms appear. Yet, despite decades of research, we are unable to accurately identify early on individuals who will progress to develop a psychotic disorder, even those who are clinically high risk for psychosis, due in part to small sample sizes and extant approaches that do not capture the multifactorial etiology of psychotic disorders. There is therefore an urgent need to substantially improve prognostic precision. Critically, accurate and robust prognostic markers are needed to understand the origins and progression of psychosis and to identify precise neurobiological targets for early treatment. Newly available large-scale multimodal data—clinical, cognitive, and neurobiological—as well as exciting recent advances in artificial intelligence models and methods that overcome limitations of extant approaches offer an unprecedented opportunity for developing accurate and robust prognostic markers for psychosis. The overarching goal of our proposal is to identify accurate and robust multimodal prognostic markers for psychosis using a novel data-driven AI-based computational framework. Building on our highly encouraging preliminary results, we will use an innovative approach combining our recent work on AI models and explainable AI methods as well as integrative theoretical models of psychosis with a wealth of newly available large-scale multimodal data from multiple consortia. The specific objectives of our proposed work are threefold. In Aim 1, we will identify prognostic markers using clinical, cognitive, and neurobiological data to predict future psychosis transition, particularly in youths at clinical high risk. In Aim 2, we will evaluate the generalizability and the temporal (longitudinal) stability of the identified prognostic markers. In Aim 3, we will determine whether the identified prognostic markers predictive of future psychosis transition in youths at clinical high risk are a characteristic trait of psychosis. Through the successful completion of the work described here, our multidisciplinary team is uniquely positioned to transform our understanding of the mechanisms associated with the risk for and development of psychotic disorders, as well as identify neurobiological targets. Ultimately, these advances will lead to the development of individualized prognostic tools and early targeted treatments for psychosis and, more broadly, advance precision psychiatry.
Grant Summary
Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk is a NIMH - National Institute of Mental Health grant providing up to $722K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $722K
2031-01-31
- 1Confirm your organization is eligible for Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk: Frequently Asked Questions
Who is eligible for the Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk?
Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk provide?
Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk provides up to $722K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk deadline?
Applications for Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk?
To apply for Multimodal Signatures Predictive of Future Psychosis Transition in Youths at Clinical High Risk, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.