A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
PROJECT SUMMARY/ABSTRACT Among the 800,000 individuals who sustain a stroke annually in the United States, up to 65% continue to expe- rience chronic moderate-to-severe impairments in one upper extremity (UE), limiting their ability to perform daily tasks. These impairments, often characterized by limited arm and hand movements, prevent the use of the paretic UE in functional tasks. Functional electrical stimulation (FES)-assisted task-specific practice is the only viable option to promote use-dependent plasticity and improve UE impairment and function. However, the ben- efits are only modest and transient, indicating that FES-assisted task-specific practice alone is insufficient in improving UE impairment and function in this more impaired population. Non-invasive neuromodulatory tech- niques [e.g., repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS)] have also been applied to cortical motor areas to augment the effects of FES-assisted task-specific practice. However, there is limited evidence supporting the effectiveness of these approaches. Thus, there is a critical need for new evidence-based multimodal interventions for moderate to severely impaired individuals who con- stitute the largest cohort of stroke survivors. Transcranial random noise stimulation (tRNS) is a new type of non- invasive brain stimulation that can boost the weak neural signals via random currents applied to the lesioned hemisphere. tRNS is more effective in modulating brain excitability than other conventional neuromodulatory techniques. When delivered during FES-assisted task-specific practice, tRNS can enhance the excitability of the surviving neural pathways to promote use-dependent plasticity and improve UE impairment and function. Indeed, our preliminary data show a profound increase in brain excitability and significant improvements in UE impair- ment and function after 6-weeks of tRNS and FES-assisted task-specific practice. Building on our preliminary data, the specific objective of this proposal is to conduct a blinded, sham-controlled, randomized clinical trial to determine the efficacy of tRNS and FES-assisted task-specific practice to improve UE impairment and function after moderate-to-severe stroke. We will also comprehensively evaluate the effect of this intervention on cortico- spinal excitability by examining the changes at multiple anatomical levels (i.e., cortical, cervicomedullary, and spinal). Our central hypothesis is that tRNS delivered during FES-assisted task-specific practice will augment the effectiveness of FES-assisted task-specific practice. The specific aims of the study are: 1) Determine the effect of tRNS and FES-assisted task-specific practice on UE impairment, 2) Determine the effect of tRNS and FES-assisted task-specific practice on UE function, and 3) Determine the effect of tRNS and FES-assisted task- specific practice on corticospinal excitability. The expected outcomes of this project include a novel multimodal therapeutic paradigm for the largest cohort of stroke survivors who currently do not have any effective interven- tions, which directly aligns with the research priority of the NIH NCMRR to study multimodal approaches to promote plasticity and sensorimotor function.
Grant Summary
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $668K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $668K
2031-05-31
- 1Confirm your organization is eligible for A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke: Frequently Asked Questions
Who is eligible for the A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke?
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke provide?
A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke provides up to $668K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke deadline?
Applications for A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke?
To apply for A Novel Multimodal Approach to Promote Motor Recovery and Plasticity after Stroke, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.