Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
PROJECT SUMMARY/ABSTRACT The proposed studies will address a major gap in our understanding of T1D, namely, to the mechanisms of cell failure from a metabolic as well as an immunological perspective. We have proposed this specific project because of a sincere belief that it has high potential to reveal significant, novel, and translatable information regarding cell dysfunction that will be of therapeutic benefit for individuals with both established T1D as well as persons with pre-diabetes. The goal is to identify components of the glucose sensing and insulin secretory machinery pathways that are altered during the natural history of disease progression in type 1 diabetes (T1D), and to characterize the metabolic and immunological signals responsible for the functional loss in cell activity that are specifically associated with this disease. This goal will be achieved by performing two lines of experimentation. Specific Aim 1 will determine the specific nature of dysfunctional bioenergetics of β cells in early stages of T1D. Using live human pancreas tissue slices from nPOD, we will employ multi-modal measurements of islet functionality. We will map molecular changes in β cell glucose metabolism to steps in T1D etiology using MALDI imaging (spatial metabolomics) and Akoya PhenoCycler (spatial proteomics). Aim 2 will determine the relationship between immune dysregulation and β cell dysfunction. Using live human pancreas tissue slices from nPOD and mouse models of T1D, we will assess the relationship between islet function and local immune microenvironment using novels tools such as fixable calcium indicators. Our team will leverage combined expertise to synergize the understanding of islet dysfunction in T1D. Phelps has expertise in islet imaging and physiology, Mathews specializes in β cell metabolism and T1D immunology, and Vander Kooi is an expert in spatial metabolomics. Together, we will provide a comprehensive analysis of the metabolic and immunologic mechanisms underlying β cell dysfunction in T1D.
Grant Summary
Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $755K for university, nonprofit, healthcare org. Applications are due 2030-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $755K
2030-04-30
- 1Confirm your organization is eligible for Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices: Frequently Asked Questions
Who is eligible for the Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices?
Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices provide?
Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices provides up to $755K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices deadline?
Applications for Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices are due 2030-04-30 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices?
To apply for Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.