ASB4 in feeding regulation
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
Project Summary/Abstract Common forms of human obesity have a polygenic genetic basis, highlighting the importance of understanding different genetic variants in body weight regulation. Multiple Genome-Wide Association Studies (GWAS) have linked Ankyrin Repeat and SOCS Box Containing 4 (ASB4) to human obesity, but how ASB4 regulates energy homeostasis is not well understood. Our preliminary experiments show that ASB4 is expressed in mouse brain regions that are crucial for feeding regulation. ASB4 deficiency leads to increased meal size and food intake following a fast, and ASB4 is required for the anorectic effects of CalcR agonists or long-acting amylin analogues. ASB4 deficiency also results in heightened consumption of dietary fat at the expense of dietary carbohydrates when two diets are offered. These preliminary findings strongly suggest that ASB4 is important for meal termination and food choice. In this application, we will determine the site of action and cellular mechanism by which ASB4 controls meal termination. We will investigate if ASB4 engages the brain reward system to regulate food choice. If successfully completed, this study will establish ASB4 as a pivotal regulator of homeostatic and hedonic feeding. As ASB4 is highly conserved between mice and humans and is linked to obesity by GWAS, this study will provide mechanistic insight into how ASB4 may regulate food intake in humans.
Grant Summary
ASB4 in feeding regulation is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $608K for university, nonprofit, healthcare org. Applications are due 2030-01-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $608K
2030-01-31
- 1Confirm your organization is eligible for ASB4 in feeding regulation from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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ASB4 in feeding regulation: Frequently Asked Questions
Who is eligible for the ASB4 in feeding regulation?
ASB4 in feeding regulation is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the ASB4 in feeding regulation provide?
ASB4 in feeding regulation provides up to $608K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the ASB4 in feeding regulation deadline?
Applications for ASB4 in feeding regulation are due 2030-01-31 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the ASB4 in feeding regulation?
To apply for ASB4 in feeding regulation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.