Bone Marrow Adiponectin Signaling and Immune Regulation
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
Abstract Hematopoiesis, the process of generating new immune cells (and other blood cells) in the bone marrow (BM), is precisely regulated by various niches, including adipocytes and their progenitors, to ensure immune competency and protection against pathogens. Adiponectin, the most abundant adipose-derived hormone, plays a crucial role in metabolic regulation; however, its function within the BM microenvironment remains largely unexplored. Obesity significantly reduces adiponectin levels, disrupting key physiological processes and increasing susceptibility to metabolic and infectious complications. While systemic adiponectin is recognized for its anti-inflammatory effects, its direct role in hematopoietic regulation and host defense against infections is not well understood. Our preliminary studies indicate that the BM adiponectin niche plays a direct role in B cell development beyond its well-established metabolic functions. Dysregulated BM adiponectin signaling compromises host defense, leading to increased susceptibility to infection-related complications. This study aims to characterize the BM adiponectin niche, identify its key cellular contributors, and determine how obesity alters adiponectin-driven cell-cell interactions within the bone marrow using adiponectin lineage-tracing models. Furthermore, we will employ receptor-deficient models to investigate how BM adiponectin signaling influences B cell hematopoiesis and impacts immune resilience. Through bone marrow transplantation experiments, we seek to assess whether adiponectin reconstitution can mitigate obesity-related disruptions in BM function. This research will provide critical insights into adipose-regulated mechanisms underlying metabolic adaptation and immune homeostasis, offering potential therapeutic strategies to address obesity- related complications. A deeper understanding of BM adiponectin’s role in metabolic and immune regulation may open new avenues for targeted interventions, ultimately improving health outcomes in obese individuals vulnerable to infection and metabolic dysfunction.
Grant Summary
Bone Marrow Adiponectin Signaling and Immune Regulation is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $755K for university, nonprofit, healthcare org. Applications are due 2030-02-28 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $755K
2030-02-28
- 1Confirm your organization is eligible for Bone Marrow Adiponectin Signaling and Immune Regulation from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Bone Marrow Adiponectin Signaling and Immune Regulation: Frequently Asked Questions
Who is eligible for the Bone Marrow Adiponectin Signaling and Immune Regulation?
Bone Marrow Adiponectin Signaling and Immune Regulation is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Bone Marrow Adiponectin Signaling and Immune Regulation provide?
Bone Marrow Adiponectin Signaling and Immune Regulation provides up to $755K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Bone Marrow Adiponectin Signaling and Immune Regulation deadline?
Applications for Bone Marrow Adiponectin Signaling and Immune Regulation are due 2030-02-28 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Bone Marrow Adiponectin Signaling and Immune Regulation?
To apply for Bone Marrow Adiponectin Signaling and Immune Regulation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.