Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis
About This Grant
PROJECT SUMMARY In cancer and chronic infection, T cells develop into a dysfunctional state called exhaustion because of persistent antigen stimulation. Exhausted T cells upregulate immune checkpoints, display dysregulated metabolism, and progressively lose effector function and the ability to persist and develop immune memory. T cell exhaustion hinders the clearance of pathogens and malignant cells by the immune system and limits the effectiveness of immunotherapies such as chimeric antigen receptor (CAR) T cell therapy. Therefore, understanding how T cells adapt to chronic antigen receptor signaling is critical for developing more effective immunotherapies. A stem-like CD8 T cell subset has been identified in chronic infections and cancers. Stem-like CD8 T cells mediate long-term immunity by self-renewal and replenishing other CD8 T cell subsets. Stem-like properties in T cells are essential for the efficacy of immunotherapies. We have identified key transcription factors that regulate the differentiation of stem-like CD8 T cells. However, the molecular program underlying the adaptation of stem-like CD8 T cells to chronic antigen receptor signaling is incompletely understood. Our recent findings show that the redox sensing KEAP1-NRF2 pathway is critical for the differentiation of stem-like CD8 T cells and adaptation of CD8 T cells to chronic antigen receptor signaling. In the proposed study, we will determine how the KEAP1-NRF2 pathway regulates the adaptation of CD8 T cells to persistent antigen receptor signaling through preventing TCR hyperactivation and promoting metabolic fitness. Our study will shed important new light on the development of more potent and efficacious immunotherapies for cancers and chronic infections. Furthermore, KEAP1 and NRF2 have been extensively investigated as potential drug targets for chronic diseases. Therefore, our findings hold significant promises for informing interventions that aim at modulating this pathway.
Grant Summary
Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis is a NCI - National Cancer Institute grant providing up to $402K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Up to $402K
2031-04-30
- 1Confirm your organization is eligible for Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis from NCI - National Cancer Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
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Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis: Frequently Asked Questions
Who is eligible for the Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis?
Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis is offered by NCI - National Cancer Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis provide?
Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis provides up to $402K per award from NCI - National Cancer Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis deadline?
Applications for Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NCI - National Cancer Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis?
To apply for Control of T-cell stemness and T-cell exhaustion by KEAP1-NRF2 axis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCI - National Cancer Institute.