HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Project Summary/Abstract HIV disease remains a considerable public health concern without a practicable cure. Drug-based therapy can control HIV but is costly, has severe side effects, and is not curative. Stem-cell based therapies have provided the only known cures for HIV infection, with only a handful of individuals functionally cured to date. However, replicating these successes has been challenging due to the high toxicities of treatment, need for transplant antigen matching, and require extensive myeloablation. However, these “cures” strongly suggest that immune system modification involving hematopoietic stem/progenitor cell (HSPC) transplantation can play a strong role allowing HIV clearance from the body. We aim to achieve a HIV-1 cure by enhancing and optimizing anti-HIV cellular immune responses through genetic modification of autologous Hematopoietic Stem/Progenitor Cells (HSPCs) with an anti-HIV Chimeric Antigen Receptor (CAR) molecule (CAR-HSPC). Unlike combined antiretroviral treatment (ART), which cannot eradicate HIV due to persistent reservoirs, our approach targets lifelong anti-HIV responses for HIV clearance. We will improve the engraftment of CAR-modified stem cells by using clinically relevant conditioning methods, maintain long-term progenitor phenotype in CAR stem cells for repopulation capability, and improve homing to the bone marrow. Additionally, we will characterize the differentiation and therapeutic effects of HSPC-derived CAR modified immune cells in various tissue reservoirs using humanized mouse models. We will develop an in vivo targeting regimen incorporating stem cell targeted nanocapsules encapsulating CAR lentivirus to generate CAR-modified stem cells in vivo and evaluate for feasibility and efficacy. Our proposed study will provide crucial insights for investigational new drug (IND) development of HSPC-based CAR immunotherapies, potentially leading to ART-free HIV suppression and a functional cure.
Grant Summary
HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $3.1M for university, nonprofit, healthcare org. Applications are due 2030-06-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $3.1M
2030-06-30
- 1Confirm your organization is eligible for HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV: Frequently Asked Questions
Who is eligible for the HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV?
HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV provide?
HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV provides up to $3.1M per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV deadline?
Applications for HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV are due 2030-06-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV?
To apply for HEMATOPOIETIC STEM/PROGENITOR CELL BASED CAR THERAPY TARGETING HIV, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.