Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis
About This Grant
Abstract The brain is highly susceptible to aging, with a notable decline in multiple brain functions. To empower strategies that restrain the influence of age on the brain, we must identify the brain- regulatory factors that undergo age-associated decline and, more importantly, identify those amenable to being boosted or rebounded in the setting of advanced age. We identified such a factor: the brain-regulatory, gamma-delta T cell (γδT) that resides in the meninges. This proposal presents several fundamental discoveries regarding the influence of age on meningeal γδT cells, their regulation by gut microbes, and gut-centric interventions that drive their rebound in advanced age. Figuring out how to fortify γδ17 cells to support brain health will have a transformative impact on human health, particularly as it relates to advanced age. This collaborative proposal endeavors to make strident leaps toward this long-term goal.
Grant Summary
Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis is a NIA - National Institute on Aging grant providing up to $612K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $612K
2031-02-28
- 1Confirm your organization is eligible for Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis: Frequently Asked Questions
Who is eligible for the Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis?
Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis provide?
Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis provides up to $612K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis deadline?
Applications for Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis?
To apply for Age-associated decline of meningeal gdT cells and their modulation by the gut-meninges axis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.