Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment
About This Grant
PROJECT SUMMARY Acetaminophen, which is found in more than 600 prescription and non-prescription medications for mild to moderate pain and fever reduction, is not restricted to pharmacies and is sold over-the-counter in many countries, including the United States. In most populations worldwide, over 50% of pregnant people report taking acetaminophen, which easily crosses the placenta and fetal blood brain barrier, potentially affecting fetal brain development. The United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) have traditionally viewed acetaminophen as posing minimal risks to the fetus when used as directed but have called for more rigorous studies and better safety data to inform their recommendations on how pain medicines are used during pregnancy. Accumulating evidence from epidemiologic and animal research highlights potential neurodevelopmental risks associated with prenatal acetaminophen exposure, yet limitations remain in the literature preventing regulatory agencies from assessing whether these associations are causal. Prior studies could be confounded by genetic or familial factors, and mechanisms linking acetaminophen with adverse neurodevelopment remain unknown, limiting our ability to develop targets for harm reduction. While adjusting for a robust set of genetic, environmental, and familial factors, this proposal aims to elucidate molecular mechanisms and genetic effect modifiers of associations between prenatal acetaminophen and adverse neurodevelopment. During the mentored K99 phase, I will receive training from leaders in pediatrics, child psychiatry and psychology, pharmacogenomics, metabolomics, and multi-omics. I will combine this training with my prior expertise in prenatal acetaminophen research and epidemiology to model associations of maternal blood biomarkers of acetaminophen with a broad spectrum of child neurodevelopmental outcomes, including ADHD. I will investigate genotype by prenatal acetaminophen interactions on child neurodevelopment (K99 Aim 1) and conduct a Metabolome-Wide Association Study (MWAS) of prenatal acetaminophen exposure (K99 Aim 2) in a single site study. Genetic expertise gained from the K99 training and Aim 1 will enable me to explore genotype by prenatal acetaminophen interactions in a meta-regression analysis of multiple cohorts (R00 Aim 3), which will require advanced methods accounting for heterogeneity in allelic effects by ancestry. Metabolomics and multi-omics expertise gained from the K99 training and Aim 2 will enable me to conduct MWAS in this multi-cohort setting, and employ multi-omics pathway integration to uncover biological pathways altered by prenatal acetaminophen (R00 Aim 4). Through this K99/R00 award, I will gain subject matter expertise in developmental psychopathology and molecular analytic skills in precision medicine, pharmacogenetics, metabolomics, and multi-omics. These research and training opportunities will prepare me to lead an independent lab harmonizing omics and epidemiologic approaches to study molecular mechanisms linking prenatal exposures with neurodevelopment.
Grant Summary
Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment is a NIMH - National Institute of Mental Health grant providing up to $244K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $244K
2028-03-31
- 1Confirm your organization is eligible for Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment: Frequently Asked Questions
Who is eligible for the Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment?
Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment provide?
Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment provides up to $244K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment deadline?
Applications for Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment?
To apply for Mechanisms and Modifiers of Prenatal Acetaminophen Exposure and Child Neurodevelopment, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.