Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes
NIDCD - National Institute on Deafness and Other Communication Disorders
About This Grant
The K99/R00 Award will support my transition to an independent researcher focused on using repetitive Transcranial Magnetic Stimulation (rTMS) to enhance post-stroke aphasia recovery. The majority of non-invasive brain stimulation (NIBS) studies, including those using rTMS, apply facilitatory stimulation to the left Inferior Frontal Gyrus (IFG) or inhibitory stimulation to its right homologue. While IFG is an important hub, the language system is widespread and complex, and its damage induce impairments that vary significantly across individuals. For instance, post-stroke aphasia often leads to anomia and semantic errors due to disruption in lexicosemantic processes. I propose to use a novel and promising target for stimulation – the Anterior Temporal Lobe (ATL) – given that evidence suggests that it plays a crucial role in lexicosemantic processing and hence may be pivotal in individuals with such impairment. Additionally, the theory of transcallosal interhemispheric imbalance hypothesize that brain lesions cause hyperactivation of the undamaged hemisphere and hypoactivation of the damaged one, justifying left hemispheric (LH) facilitation and right hemispheric (RH) inhibition. However, this model does not fully explain the complex involvement of the RH in post-stroke aphasia recovery. Furthermore, while rTMS shows promise in improving post-stroke language impairments, individual responses vary, necessitating a better understanding of factors influencing its efficacity. To address these gaps, I propose a three-arm randomized clinical trial involving 60 individuals with post-stroke aphasia. The study will compare facilitatory rTMS targeting the left ATL, inhibitory rTMS targeting the right ATL, and sham stimulation. By tailoring rTMS targets to participants’ clinical profiles, we aim to improve language processing outcomes (Aim 1). I will investigate how RH inhibition versus LH facilitation affects language recovery. Using resting-state and task-based functional Magnetic Resonance Imaging (fMRI), I will explore the mechanisms underlying each stimulation type and assess the relevance of the theory of transcallosal interhemispheric imbalance (Aim 2). I will also study how lesion localization and neural disconnections influence responses to brain stimulation using lesion- and connectome- symptom mapping (LSM/CSM) techniques (Aim 3). This research builds on my Ph.D. work, which focused on tailoring rTMS to specific post-stroke language impairments and extends it to address lexicosemantic impairments. The K99 phase will primarily develop my expertise in fMRI and LSM/CSM methodologies, supporting my progression to independent scientist in the R00 phase and enabling future investigations into NIBS for aphasia recovery, improving outcomes and understanding the underlying mechanisms of these stimulations.
Grant Summary
Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes is a NIDCD - National Institute on Deafness and Other Communication Disorders grant providing up to $146K for university, nonprofit, healthcare org. Applications are due 2028-02-29 (open). Check eligibility and apply with FindGrants.
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Up to $146K
2028-02-29
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Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes: Frequently Asked Questions
Who is eligible for the Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes?
Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes is offered by NIDCD - National Institute on Deafness and Other Communication Disorders and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes provide?
Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes provides up to $146K per award from NIDCD - National Institute on Deafness and Other Communication Disorders. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes deadline?
Applications for Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes are due 2028-02-29 (open). Because deadlines can change, verify the date with the funder, NIDCD - National Institute on Deafness and Other Communication Disorders, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes?
To apply for Recovery from Post-Stroke Aphasia With rTMS Targeting The Anterior Temporal Lobe: Interhemispheric Activation Changes And Lesion-Connectome-Based Predictive Outcomes, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDCD - National Institute on Deafness and Other Communication Disorders.