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View full policyBiomarkers for Recovery of Veterans with Severe Spinal Cord Injury
About This Grant
Accurate prognosis prediction is essential for planning rehabilitation programs and setting functional goals of veterans with spinal cord injury (SCI). A gap in our knowledge is how to identify veterans with SCI with greater potential to recover early after injury. The overall goal of this proposal is to examine the potential of physiological and blood-based biomarkers to predict neurological and functional recovery in veterans with motor complete and incomplete SCI during inpatient rehabilitation. To address this question, we propose to implement a multisite clinical trial that will involve for VA sites: Edward Hines Jr. VA Hospital (leading site), Louis Stokes Cleveland VA Medical Center, James A. Haley Veterans' Hospital, and West Roxbury VA Medical Center to assure geographic and socio-demographic variation, and successful recruitment goals. In Aim 1, we will investigate the relationship between spasticity and neurological and functional recovery in veterans with SCI. A relationship has been found between residual corticospinal connectivity and severity of spasticity following SCI. We propose to measure spasticity in muscles below the level of injury bilaterally in veterans with SCI using clinical and kinematic outcomes at admission to and discharge from inpatient rehabilitation. Neurological recovery will be assessed by the International Standards for Neurological Classification of Spinal Cord Injury exam and functional recovery will be assessed by the Functional Independence Measure exam and quality of life outcomes. In Aim 2, we propose to determine the relationship between blood-based biomarkers and neurological and functional recovery in veterans with SCI. Brain-derived neurotrophic factor (BDNF) and single-nucleotide polymorphisms in BDNF play a critical role in promoting neuronal plasticity. We propose to measure serum levels of BDNF by using enzyme-linked immunosorbent assays (ELISA) at admission to and discharge from inpatient rehabilitation. The proposed experiments will provide new knowledge that could help to identify sensitive and easy-to-use biomarkers to predict recovery in veterans with SCI and affect the standard of care in the VA health care medical system. The absence of well-accepted biomarkers to predict recovery in veterans with SCI underlines the importance of these investigations.
Grant Summary
Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury is a NIH grant providing funding that varies by award for university, nonprofit, healthcare org. Applications are due 2029-09-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $0K
2029-09-30
- 1Confirm your organization is eligible for Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury from NIH, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIH before the deadline.
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Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury: Frequently Asked Questions
Who is eligible for the Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury?
Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury is offered by NIH and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury provide?
Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury provides an amount that varies by award per award from NIH. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury deadline?
Applications for Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury are due 2029-09-30 (open). Because deadlines can change, verify the date with the funder, NIH, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury?
To apply for Biomarkers for Recovery of Veterans with Severe Spinal Cord Injury, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIH.