Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression
About This Grant
PROJECT SUMMARY/ABSTRACT This proposal aims to elucidate a potential neurobiological mechanism of stress-induced social behavior deficits. Chronic stress is well-known to contribute to neuropsychiatric disorders such as major depressive disorder and post-traumatic stress disorder, and social dysfunction is often cited by patients as a major quality of life problem. Based on previous work from the lab, transposable element (TE) dysregulation has been identified as a driver of social behavior deficits in stress- naïve mice. TEs are known to be silenced in the genome by KRAB zinc finger protein (KZFP) transcription factors, which collectively bind the transcriptionally repressive cofactor TRIM28. Using novel synthetic TRIM28 variants delivered into the medial prefrontal cortex (mPFC) of male and female mice, this study will probe the connection between chronic stress, mPFC TE stability, and social behavior. The synthetic TRIM28 variants, TRIM28WT and TRIM28VPR, exert opposing forms of transcriptional control, with TRIM28WT acting as a gene repressor and TRIM28VPR as an activator. Aim 1 seeks to determine the behavioral outcomes of applying synthetic TRIM28 variants to mice who have undergone chronic social stress, thereby providing training in the application of translationally relevant chronic stress paradigms. Restabilizing TEs via TRIM28WT is predicted to reverse stress-induced social behavior deficits. Aim 2 seeks to characterize the mPFC transcriptional correlates of these behaviors, in terms of both canonical genes and TEs, using bulk RNA sequencing of microdissected mPFC tissue. Moreover, Aim 2 will relate these gene transcriptional changes to known changes induced by chronic social stress in the absence of TRIM28 manipulations. This will clarify the gene and TE transcriptional responses to chronic stress and will provide training in the analysis of complex bioinformatic data. Collectively, this project aims to understand the role of TE stability in the mPFC in stress-induced social behavior deficits, ideally culminating in a novel approach to address the gap in quality of life for people with chronic stress associated neuropsychiatric disorders.
Grant Summary
Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression is a NIMH - National Institute of Mental Health grant providing up to $46K for university, nonprofit, healthcare org. Applications are due 2029-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $46K
2029-06-30
- 1Confirm your organization is eligible for Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression: Frequently Asked Questions
Who is eligible for the Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression?
Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression provide?
Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression provides up to $46K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression deadline?
Applications for Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression are due 2029-06-30 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression?
To apply for Dysregulating brain transposable elements to study stress-induced social behaviors and gene expression, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.