Defining microbe-induced immune alterations precluding allergic airway eosinophilia
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
ABSTRACT Asthma is an inflammatory disorder of the respiratory tract triggered in response to inhalation of stimuli like allergens. It is the most common chronic disease in children worldwide, making it a major public health concern. A hallmark feature of asthma is the excessive eosinophil recruitment to the airways (referred to as allergic airway eosinophilia) which inflicts tissue damage, airway wall remodeling, and reduced gas exchange in the affected lungs. The hygiene hypothesis posits that exposure to commensal microbes may educate our immune system and direct it away from development of allergies and asthma. Relevant to this, our preliminary data also suggests that inhalation experience with the frequent human nasopharynx-colonizing bacteria Streptococcus pneumoniae (Spn) confers protection against allergic airway eosinophilia. How such inhaled microbial experience may mechanistically preclude allergic airway eosinophilia, however, remains unclear. In this proposal we will test the hypothesis that Spn experience protects against allergic airway eosinophilia by potentiating a Treg- and a cDC1- dependent immunoregulatory axis; to be tested as part of Aims 1 and 2 respectively. Aim 1 will determine whether inhaled Spn experience is protective due to the production of IL-10 by regulatory T cells (Tregs) formed during bacterial encounter, and Aim 2 will determine whether Spn confers protection through the activity of an enriched cDC1 pool during allergen encounter. These studies will be accomplished using novel genetically engineered mouse lines, human relevant murine models of pneumococcal experience and asthma, spectral flow cytometry, and single cell RNA sequencing. Findings from these innovative studies will delineate pathways that may be exploited as targets for next-generation preventative and treatment strategies against asthma. What is more, this proposal will also support the applicant in scientific, professional, technical, career, and personal development through guidance by an expert mentoring team and dissertation committee, use of state-of-the-art experimental techniques, enrollment in a tailored course curriculum, engagement in workshops and seminars, and engagement in an array of science communication and mentorship opportunities. The University of Michigan boasts elite academic training; connections and collaborations with experts in the fields of immunology, microbiology, pulmonology, and allergy; and cutting-edge facilities to achieve the proposed aims. Completion of this proposal will additionally support the applicant’s thorough and rigorous training in creative experimental design, microbiological and immunological techniques, and data interpretation and presentation that will ensure her future success as an independent researcher and principal investigator.
Grant Summary
Defining microbe-induced immune alterations precluding allergic airway eosinophilia is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $50K for university, nonprofit, healthcare org. Applications are due 2029-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $50K
2029-06-30
- 1Confirm your organization is eligible for Defining microbe-induced immune alterations precluding allergic airway eosinophilia from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Defining microbe-induced immune alterations precluding allergic airway eosinophilia: Frequently Asked Questions
Who is eligible for the Defining microbe-induced immune alterations precluding allergic airway eosinophilia?
Defining microbe-induced immune alterations precluding allergic airway eosinophilia is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Defining microbe-induced immune alterations precluding allergic airway eosinophilia provide?
Defining microbe-induced immune alterations precluding allergic airway eosinophilia provides up to $50K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Defining microbe-induced immune alterations precluding allergic airway eosinophilia deadline?
Applications for Defining microbe-induced immune alterations precluding allergic airway eosinophilia are due 2029-06-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Defining microbe-induced immune alterations precluding allergic airway eosinophilia?
To apply for Defining microbe-induced immune alterations precluding allergic airway eosinophilia, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.