Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) and psychiatric disorders are highly prevalent globally and interconnected through biological and behavioral pathways. Psychiatric disorders are thought to exacerbate TB severity, mortality, drug resistance and risk for disease progression. Among people with TB, an estimated 50% and 30% experience depression and post-traumatic stress disorder (PTSD), respectively. While preliminary evidence suggests that psychiatric symptoms may increase risk of TB, evidence from high-quality longitudinal data sources remains scarce. Furthermore, pregnancy may be a critical period when mental health service integration can reduce TB incidence among mothers and children. The overall objective of the proposed project is to estimate the impact of depressive and PTSD symptoms on tuberculosis disease risk among mothers and children. Aim 1 will focus on estimating the effect of depressive and PTSD symptoms on TB risk among mothers. Aim 2 will focus on estimating the effect of maternal depressive and PTSD symptoms during pregnancy on child risk for TB disease and infection. Data will come from the Drakenstein Child Health Study (DCHS), a multi-morbidity birth cohort in Western Cape, South Africa, which follows mothers and children from 28-32 weeks’ gestation through age 10. Aim 1 will use a nested case-control design with conditional logistic regression and Aim 2 will use multivariable Cox proportional hazards regression. This will be the first study to examine how PTSD symptoms predispose people to developing TB and how maternal mental health during pregnancy influences TB risk in children. Understanding how psychiatric disorders impact susceptibility to TB disease and infection will lay the foundation for research on strategic mental health screening and interventions to achieve TB reduction and elimination. This research aligns with NIAID’s mission to advance understanding of infectious diseases to inform response to reemerging disease threats, including the 2026 council-approved focus on the role of comorbidities on TB disease progression. My mentoring team has outstanding expertise in TB epidemiology, psychiatric epidemiology, and biostatistical methods, and is fully committed to supporting me in my training and professional development. We have designed a training plan which includes coursework and workshops in psychiatric and TB epidemiology, career development, and mentored research. Through this fellowship, I will develop the skills to become an independent researcher at the intersection of mental health and infectious disease.
Grant Summary
Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $50K for university, nonprofit, healthcare org. Applications are due 2028-06-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $50K
2028-06-30
- 1Confirm your organization is eligible for Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children: Frequently Asked Questions
Who is eligible for the Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children?
Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children provide?
Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children provides up to $50K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children deadline?
Applications for Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children are due 2028-06-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children?
To apply for Effect of depressive and PTSD symptoms on risk for tuberculosis disease among mothers and children, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.