Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk
About This Grant
Psychiatric disorders are increasingly conceptualized as disorders of brain development. White matter (WM) structure develops rapidly in adolescence and has been linked to many psychiatric illnesses. However, the neurobiological mechanisms linking WM development, transdiagnostic psychiatric symptoms, and genetic risk for psychopathology remain poorly understood. This proposal tests the central hypothesis that transdiagnostic psychiatric symptoms and genetic risk will be associated with WM that undergoes the most protracted development: superficial regions of WM tracts connected to higher-order association cortices. We will leverage the large, longitudinal Adolescent Brain Cognitive Development (ABCD) study (n=11,875; ages 9-16), which includes multi-shell diffusion MRI, clinical, and genotype data. In Aim 1, we will characterize within-individual, along-tract WM development and we will evaluate whether associations with transdiagnostic symptoms are strongest in superficial WM regions adjacent to higher-order association cortices. In Aim 2, we will assess how polygenic risk scores (PRS) for transdiagnostic psychiatric illness relate to spatially precise WM microstructure metrics. We will assess whether PRS effects are strongest in superficial WM regions adjacent to higher-order association cortices. Together, this work will identify brain regions where protracted WM maturation is linked to transdiagnostic symptoms and genetic risk, advancing our understanding of how WM development is related to symptomatology and genetic liability for trans-diagnostic psychiatric illness.
Grant Summary
Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk is a NIMH - National Institute of Mental Health grant providing up to $55K for university, nonprofit, healthcare org. Applications are due 2029-05-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $55K
2029-05-31
- 1Confirm your organization is eligible for Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk: Frequently Asked Questions
Who is eligible for the Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk?
Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk provide?
Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk provides up to $55K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk deadline?
Applications for Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk are due 2029-05-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk?
To apply for Mapping Person-Specific and Spatially Precise White Matter Development to Transdiagnostic Psychopathology and Polygenic Risk, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.