Substance Use Grants (2026)

Substance Abuse and Mental Health Services Adminis

<p><span style="color: rgb(74, 74, 74);">The purpose of this program is to prevent and reduce substance use and overdose among American Indian and Alaska Native youth and young adults through age 24 by building community-driven prevention systems, services, and partnerships. Your organization will use evidence-based and locally tailored strategies.</span></p>

Substance Abuse and Mental Health Services Adminis

Tribal Behavioral Health Substance Use Prevention

Substance Abuse and Mental Health Services Adminis

<p>The purpose of the TOR program is to assist in addressing the overdose crisis in Tribal communities by increasing access to FDA-approved medications for the treatment of opioid use disorder (MOUD), and supporting the continuum of prevention, treatment, and recovery support services for opioid use disorder (OUD) and co-occurring substance use disorders, and stimulant misuse and use disorders, including those involving cocaine and methamphetamine.</p>

Substance Abuse and Mental Health Services Adminis

Rural Opioid Technical Assistance Centers

Substance Abuse and Mental Health Services Adminis

Preventing Youth Overdose: Treatment, Recovery, Education, Awareness and Training

Substance Abuse and Mental Health Services Adminis

Tribal Opioid Response

Substance Abuse and Mental Health Services Adminis

Grants to Expand Substance Use Disorder Treatment Capacity in Adult and Family Treatment Drug Courts

Health Resources and Services Administration

The MMHSUD Program helps improve maternal mental health and substance use disorder outcomes for pregnant and postpartum women by providing obstetric, primary care, and other maternal health providers with timely access to teleconsultation, training, and care coordination support including resource and referrals.

Health Resources and Services Administration

Screening &amp; Treatment for Maternal Mental Health and Substance Use Disorders (MMHSUD)

Health Resources and Services Administration

Rural Communities Opioid Response Program (RCORP)-Technical Assistance

Substance Abuse and Mental Health Services Adminis

Medication-Assisted Treatment - Prescription Drug and Opioid Addiction

Substance Abuse and Mental Health Services Adminis

First Responders-Comprehensive Addiction and Recovery Act

National Institutes of Health

The purpose of this notice of funding opportunity (NOFO) is to establish a Center that trains researchers in formal product development for new substance use disorder (SUD) pharmacotherapeutics and to advance the best concepts through initial experiments via technical and financial support.

National Institutes of Health

Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support (U54 Clinical Trial Not Allowed)

National Institutes of Health

Limited Competition: Growing Great Ideas: Research Education Course in Entrepreneurship and Product Development for Researchers Studying Drug Use, Drug Misuse, and Drug Addiction (UE5 Clinical Trial Not Allowed)

National Institutes of Health

<p>The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.</p>

National Institutes of Health

<p>The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.</p>

National Institutes of Health

Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional)

National Institutes of Health

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

National Institutes of Health

The purpose of this notice of funding opportunity (NOFO) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.

National Institutes of Health

Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

National Institutes of Health

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

National Institutes of Health

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

National Institutes of Health

Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

National Institutes of Health

The goal of this notice of funding opportunity (NOFO) is to address the opioid crisis and/or overdose events by supporting action-oriented research, accelerating the translation of addiction epidemiology, prevention, treatment services, and recovery research to practice. Proposed studies may target the individual, provider, organizational, community, or system level. This initiative prioritizes replicable and scalable approaches for accelerating the routine use of effective, evidence-based prevention, treatment and recovery interventions and services. The translation of research to practice and research relevant to chronic pain comorbid with substance use is also a priority. Research may deploy a variety of methods and approaches, including but not limited to identifying and characterizing malleable factors, developing and testing interventions and implementation strategies, deploying and testing collaborative data science approaches, and/or developing and testing approaches that integrate the collaboration of researchers and decision-makers at any levels (e.g., clinical-, health system-, public health- or policy-level).

National Institutes of Health

HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)

Indian Health Service

The purpose of this NOFO is to strengthen public health capacity of 1) Tribal Epidemiology Centers (TECs) and 2) the Tribes, Tribal Organizations, Urban Indian organizations, and Intertribal Consortiums that they support to fulfill the seven functions of TECs as outlined in the Indian Health Care Improvement Act (IHCIA) at 25 U.S.C. 1621m(b). It is the intent of IHS to fund sufficient TECs to serve Tribes and Urban Indian communities in all 12 IHS administrative areas and serving the Urban population as a consolidated Area. Applicant objectives may include activities beyond the required activities but must address all required activities.

Substance Abuse and Mental Health Services Admin

Behavioral Health and Community Safety Partnerships

Centers for Disease Control-GHC

Activities under this Notice of Funding Opportunity (NOFO) should focus on protecting and improving public health globally by: 1) strengthening public health surveillance systems; 2)improving the public health surveillance workforce; 3) improving the interface between public health disease surveillance and laboratory systems; 4) reinforcing emergency surveillance preparedness; 5) enhancing electronic disease surveillance platforms and systems; and 6)enhancing the use of surveillance data for public health action. This NOFO is intended to support global health security partners to develop or continue the implementation of surveillance activities that focus on protecting and improving public health globally through strategic planning, policy, strengthening surveillance capacities and systems through partnerships. These surveillance systems should build and improve regional and country capacities to detect, respond, control, and prevent infectious diseases and emerging threats; strengthen border health security; and mitigate public health events of international concern (PHEICs) or other global health issues. The implementing partner(s) will work closely with Ministries of Health, CDC country offices, and other stakeholders to assess existing surveillance systems, identify gaps, and propose solutions to enhance system performance. Activities will include the development and adaptation of protocols, training materials, and guidance documents, as well as the integration of surveillance data into actionable insights for decision-making. The partner will also support cross-sectoral collaboration to address One Health priorities, facilitate the use of innovative tools and technologies, and provide workforce development opportunities to build local capacity. This NOFO aligns with the broader mission of the DGHP to improve global health security by ensuring countries are equipped to prevent, detect, and respond to public health threats effectively. The implementing partner will play a critical role in advancing surveillance systems that contribute to timely interventions and evidence-based policy decisions, ultimately safeguarding public health at national and global levels.

National Institutes of Health

<p>The purpose of this Notice of Funding Opportunity (NOFO) is to stimulate HIV/AIDS research within the scientific mission areas of the National Institute on Deafness and Other Communications Disorders (NIDCD). Applications should address high priority HIV/AIDS research outlined by the NIH Office of AIDS Research (OAR) (https://www.oar.nih.gov/hiv-policy-and-research/research-priorities) in the areas of hearing, balance, taste, smell, voice, speech, and language.For applications proposing a clinical trial, only low risk clinical trials will be supported.</p>

Substance Abuse and Mental Health Services Adminis

<p>The purpose of this program is for the prevention of suicide, suicide attempts, and deaths by suicide among American Indian/Alaska Native youth and young adults through age 24 in Tribal communities.</p>

Office of the National Coordinator

While working to implement Cures Act provisions, ONC identified gaps with respect to leveraging EHR data to support population-level analyses and delivery of services, as well as integrating clinical knowledge into routine clinical practice. The reasons for these gaps range from a lack of data standards and interoperability to the digitization, integration, and presentation of new evidence into clinical workflows in safe, useful, and useable ways. Therefore, this funding opportunity will support innovative and breakthrough solutions critical to maximize the potential of health IT and achieve the goal of a transformed health care delivery system through various methods, such as:• Determining the fundamental questions, the answers to which will identify barriers to nationwide interoperability and electronic exchange of health data.• Engaging the health IT industry, along with academic researchers, to identify and develop innovative solutions that address barriers to interoperability.• Disseminating findings from research while fostering collaboration, advancement, and implementation of solutions and lessons learned with the health IT industry.

Health Resources and Services Administration

The Maternal Produce Prescription Program (MP3) will provide grants to develop and implement community-based produce prescription programs and related nutrition education for maternal populations at risk of poor health outcomes due to nutrition insecurity and other health-related factors.

Health Resources and Services Administration

The purpose of this program is to support a Regional Pediatric Prevention Network (RPPN). The RPPN strengthens local and regional capacity to care for children during disasters and emergencies through community partnerships, coordinated pediatric preparedness, and dissemination of research-informed pediatric disaster care. The RPPN will include at least 10 children"s hospitals, or their university pediatric partners, funded through two primary awards. It will also include community partners working with these hospitals. Each of the 10 Children"s Hospital centers will advance pediatric emergency and disaster preparedness at the local, regional, and national levels, including for children with special health care needs and behavioral health concerns, children living in poverty, and children in rural, remote, and tribal areas.

Office of the Assistant Secretary for Health

The Office of the Assistant Secretary for Health (OASH) Office on Women's Health (OWH) announces the anticipated availability of funds for Fiscal Year (FY) 2026 grants under the authority of section 229 of the Public Health Service (PHS) Act (42 U.S.C. § 237a) and section 1703(a) of the PHS Act (42 U.S.C. § 300u-2(a)). Those grants are funded through the Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations Act, 2026.This notice solicits applications for initiatives that seek to address sexual violence by founding or replicating new safe homes for sexually exploited and/or abused women or girls. These safe homes must provide longer-term housing for months or years–sufficient to serve the rehabilitative needs of the populations served–as opposed to emergency shelter, along with comprehensive multidisciplinary care that addresses the physical, psychological, emotional, social, and educational needs of the girls and women they serve. Grantees are expected to strengthen partnerships between state- and/or community-level providers which may include healthcare systems, domestic or sexual violence organizations, law enforcements, behavioral health providers, substance use disorder treatment providers, or education providers. By partnering with healthcare and community organizations, these safe homes would improve healthcare providers' ability to help victims of violence and improve prevention of further violence and re-traumatization by providing female victims of sexual exploitation and/or abuse with the comprehensive, therapeutic, and staffed, around-the-clock care that they need.